C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/48 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2545426
Methods for testing and assessing whether an agent that inhibits cdk activity produces a therapeutic response in a mammal, with a focus on detecting the inhibition of phosphorylation of the retinoblastoma protein (Rb) at putative phosphorylation sites, are disclosed. Also disclosed are methods for monitoring pharmacodynamic drug action of a cdk inhibitor in a surrogate tissue(s) of a mammal, preferably a rat, mouse or human.
Depinto Wanda Eve
Yin Xuefeng
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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