Interleukin-1 and tumor necrosis factor-a modulators;...

Details Interleukin-1 and tumor necrosis factor-a modulators;... Interleukin-1 and tumor necrosis factor-a modulators;...

C - Chemistry, Metallurgy

07

C

C07C 233/58 (2006.01) A61K 31/16 (2006.01) A61P 35/00 (2006.01) C07C 49/557 (2006.01)

Patent

CA 2613366

Compounds are disclosed that have the chemical structure of Formula (II), (IIA) and (IIB) and their prodrug esters and acid-addition salts, and that are useful as Interleukin-1 and Tumor Necrosis Factor-a modulators, and thus are useful in the treatment of various diseases, wherein the R groups are defined in the claims.

L'invention concerne des composés présentant une structure chimique de formule (II), (IIA) et (IIB) ainsi que leurs esters de promédicament et leurs sels d'addition acide, lesquels sont utiles en tant que modulateurs de facteur de nécrose tumorale alpha et d'interleukine-1, ainsi que dans le traitement de diverses maladies, les groupes R étant tels que définis dans les revendications.

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