Heterocyclic containing biphenyl ap2 inhibitors and method

Details Heterocyclic containing biphenyl ap2 inhibitors and method Heterocyclic containing biphenyl ap2 inhibitors and method

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/41 (2006.01) A61K 31/4164 (2006.01) A61K 31/4178 (2006.01) A61K 31/4196 (2006.01) A61K 31/4245 (2006.01) A61K 45/06 (2006.01) C07D 207/323 (2006.01) C07D 207/452 (2006.01) C07D 231/12 (2006.01) C07D 233/54 (2006.01) C07D 233/56 (2006.01) C07D 233/60 (2006.01) C07D 233/68 (2006.01) C07D 249/12 (2006.01) C07D 257/10 (2006.01) C07D 263/30 (2006.01) C07D 263/32 (2006.01) C07D 263/34 (2006.01) C07D 307/42 (2006.01) C07D 317/22 (2006.01) C07D 333/20 (2006.01) C07D 403/00 (2006.01) C0

Patent

CA 2366871

aP2 inhibiting compounds are provided having formula (I) wherein R1, R2, R3, R4, X-Z and (a) are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, employing such aP2 inhibitor or a combination of such aP2 inhibitor and another antidiabetic agent such as metformin, glyburide, troglitazone and/or insulin.

L'invention a trait à des composés inhibant l'aP2 présentant la formule (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, X-Z et (a) ont la notation définie dans la description. L'invention concerne également une méthode de traitement du diabète et de maladies apparentées, en particulier du diabète de type II, utilisant ledit inhibiteur d'aP2 ou une combinaison de cet inhibiteur d'aP2 et d'un autre agent antidiabétique tel que la metformine, le glibenclamide, la troglitazone et/ou l'insuline.

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