C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/113 (2006.01) A61K 31/403 (2006.01) A61K 31/407 (2006.01) A61K 31/517 (2006.01) C07D 209/54 (2006.01) C07D 403/12 (2006.01) C07D 497/10 (2006.01)
Patent
CA 2638107
Formula (I): The present invention relates to spiro compounds of formula (I), processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of disease states such as cancers associated with protein tyrosine kinases, especially epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF), to their method of use as medicaments and to their method of use in the manufacture of medicaments for use in the production of inhibition of tyrosine kinase reducing effects in warm-blooded animals such as humans.
Formule (I) : la présente invention concerne des composés spiro répondant à la formule (I), des procédés pour leur préparation, des compositions pharmaceutiques contenant ces composés en tant que principe actif, des procédés pour le traitement de pathologies telles que des cancers associés à des protéines tyrosine kinases, en particulier à un facteur de croissance épidermique (EGF) et à un facteur de croissance endothélial vasculaire (VEGF), leur procédé d~utilisation en tant que médicaments et leur procédé d~utilisation dans la fabrication de médicaments utilisés pour inhiber des effets réducteurs de la tyrosine kinase chez des animaux à sang chaud tels que des humains.
Chen Guoqing Paul
Na
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