C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) C12N 15/11 (2006.01) C12Q 1/42 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2370547
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-5, and polypeptide variants thereof that stimulate dephosphorylation of DSP-5 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-5 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
L'invention porte sur des compositions et procédés pour le traitement d'états associés à la prolifération, à la différenciation et à la survie des cellules, et en particulier sur la phosphatase DSP-5 à spécificité double, et sur ses variétés qui stimulent la déphosphorylation des substrats de la DSP-5. Les polypeptides peuvent par exemple servir à identifier des anticorps, et autres agents inhibiteurs de l'activité de la DSP-5. Ces polypeptides et agents peuvent servir à moduler la prolifération, la différenciation et la survie des cellules.
Luche Ralf M.
Wei Bo
Ceptyr Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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