Agent for regulating bone formation

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 1/02 (2006.01) A61P 19/00 (2006.01) A61P 19/02 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2591715

It is intended to provide a preventive, ameliorating and/or therapeutic agent for a disease caused by the rupture of equilibrium in bone formation and bone resorption. A decoy of the invention induces normal bone metabolism by inhibiting a differentiation-inducing factor for a cell associated with bone metabolism. For example, by inhibiting NF-.kappa.B, which is a transcriptional regulatory factor that regulates the differentiation of an osteoclast, bone resorption can be controlled. Because the method utilizes a mechanism that is different from that of a conventional agent, an effect can be expected in a case where a conventional agent has not exerted any effect.

La présente invention a pour objet un agent prophylactique, soulageant et/ou thérapeutique pour le traitement d'une maladie causée par la rupture de l'équilibre entre la formation d'os et la résorption d'os. Un agent de contrôle selon l'invention agit en tant que leurre et induit un métabolisme osseux normal, en inhibant un facteur induisant la différentiation au sein d'une cellule intervenant dans le métabolisme osseux. Par exemple, en inhibant NF-.kappa.B, un facteur de régulation de transcription qui régule la différentiation d'un ostéoclaste, il est possible de réguler la résorption des os. Du fait de l'utilisation par la méthode d'un mécanisme différent de celui d'un agent conventionnel, il est possible d'obtenir un effet positif dans des cas où un agent conventionnel n'a induit aucun effet.

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