Animal immunocontraceptives expressed in plants and uses...

Details Animal immunocontraceptives expressed in plants and uses... Animal immunocontraceptives expressed in plants and uses...

A - Human Necessities

61

K

A61K 39/00 (2006.01) A01H 5/00 (2006.01) A23K 1/18 (2006.01) A61K 9/00 (2006.01) A61K 38/44 (2006.01) A61P 15/16 (2006.01) A61P 15/18 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2498910

The present invention provides immunocontraceptive vaccines comprising a genetically engineered plant that has been modified to produce the sperm-specific protein lactate dehydrogenase-C (LDH-C). When animals such as rodents eat this plant, their immune systems produce antibodies that attack their sperms. Not only would the males have less viable sperm, the females would also have antibodies to sperm entering their reproductive systems. Immunocontraception is an attractive method for reducing the population size of animals with high fecundity, and sterilizing animals using such immunocontraceptives can reduce targeted animal populations to acceptable levels in an efficient, cost-effective, humane and, importantly, a species-specific manner.

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