C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/14 (2006.01) G01N 33/48 (2006.01) G01N 33/52 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2419295
Methods and kits are provided for separating a mixture of proteins in a biological sample. Methods for detecting and profiling proteins in biological samples by the separation method and kits are also provided. These methods are particularly useful in assessing damage to cells such as cardiac and skeletal muscle cells and in the early clinical diagnosis of myocardial damage by detection of myofilament proteins in serum of a subject.
L'invention concerne des procédés et des trousses servant à séparer un mélange de protéines dans un échantillon biologique ; des procédés de détection et de profilage de protéines dans des échantillons biologiques utilisant le procédé de séparation et les trousses. Ces procédés sont particulièrement utiles dans l'évaluation de lésions cellulaires, p. ex. de cellules de muscle cardiaque et squelettique, et dans le diagnostic clinique précoce d'affection du myocarde par la détection de protéines de myofilaments dans le sérum d'un sujet.
Colantonio David
Labugger Ralf
Neverova Irena
Simpson Jeremy A.
Van Eyk Jennifer E.
Queen's University At Kingston
Scribner Stephen J.
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