Differentially expressed leishmania genes and proteins

Details Differentially expressed leishmania genes and proteins Differentially expressed leishmania genes and proteins

C - Chemistry, Metallurgy

12

N

C12N 15/30 (2006.01) A61K 39/008 (2006.01) C07K 14/44 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2105538

Differentially expressed Leishmania genes and proteins are described. One differentially expressed gene (A2) is expressed at significantly elevated levels (more than about 10 fold higher) in the amastigote stage of the life cycle when the Leishmania organism is present in macrophages than in the free promastigote stage. The A2 gene encodes a 22 kD protein (A2 protein) that is recognized by kala-azar convalescent serum and has amino acid sequence homology with an S-antigen of Plasmodium falciparum Vietnamese isolate VI. Differentially expressed Leishmania genes and proteins have utility as vaccines, diagnostic reagents, as tools for the generation of immunological reagents and the generation of attenuated variants of Leishmania.

Description de gènes différentiellement exprimés et de protéines de Leishmania. Un gène différentiellement exprimé (A2) est exprimé à des niveaux significativement élevés (plus d'environ 10 fois plus) au stade amastigote du cycle biologique lorsque l'organisme Leishmania est présent dans les macrophages qu'au stade promastigote libre. Le gène A2 code pour une protéine de 22 kD (protéine A2) qui est reconnue par le sérum de phase convalescente de kala-azar et qui présente une homologie de séquence d'acides aminés avec un antigène S de l'isolat vietnamien VI de Plasmodium falciparum. Les gènes différentiellement exprimés et les protéines de Leishmania sont utiles comme vaccins et agents diagnostiques, ainsi que pour la production de réactifs immunologiques et de variants atténués de Leishmania.

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