Skin care composition comprising a retinoid, an acid and...

A - Human Necessities – 61 – K

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Details

A61K 8/67 (2006.01) A61K 8/365 (2006.01) A61K 8/41 (2006.01) A61Q 19/00 (2006.01)

Patent

CA 2407857

There are provided compositions which include a retinoid and preferably retinol; a dermatologically active acid; and a volatile base, such as ammonium hydroxide. Another embodiment of the invention includes compositions comprising a retinoid and preferably retinol; a dermatologically active acid; a volatile base; and a second neutralizing agent. There are also provided compositions which include a retinoid, a neutralized ammonium salt of a dermatologically active acid, and optionally a neutralized salt, other than ammonium salt, of an acid. Further provided are methods for reducing fine lines, wrinkles, skin roughness, and pore size and for increasing the clarity of a skin surface, cellular turnover, skin radiance, skin smoothness, skin permeation or collagen synthesis in a mammal in need thereof. Compositions as described above are administered topically to the skin of the animal.

Ces compositions renferment un rétinoïde et, de préférence, du rétinol, un acide actif du point de vue dermatologique, et une base volatile, telle que de l'hydroxyde d'ammonium. Un autre mode de réalisation de l'invention porte sur des compositions renfermant un rétinoïde et, de préférence, du rétinol, un acide actif du point de vue dermatologique, et une base volatile ainsi qu'un second agent neutralisant. L'invention concerne également des compositions renfermant un rétinoïde, un sel d'ammonium neutralisé d'un acide actif du point de vue dermatologique et, éventuellement, un sel neutralisé, autre qu'un sel d'ammonium, d'un acide. Cette invention porte, de surcroît, sur des procédés permettant de réduire des ridules, des rides, la rugosité cutanée ainsi que la taille des pores et permettant également d'accentuer la clarté de l'épiderme, d'améliorer le renouvellement cellulaire, le rayonnement cutané, le lissé cutané, la perméation cutanée ou la synthèse du collagène chez un mammifère. Les compositions décrites ci-dessus sont administrées localement.

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