Substituted pyrroles

Details Substituted pyrroles Substituted pyrroles

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/435 (2006.01) C07D 471/06 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2010636

Compounds of the formula (see formula I) wherein R represents hydrogen or hydroxy, R1 and R2 together represent a group of the formula -(CH2)n- and R7 represents hydrogen or R1 and R7 together represent a group of the formula -(CH2)n- and R2 represents hydrogen: R3 represents an aryl or heteroaryl group; R4, R5 and R6 each independently represent hydrogen, halogen, alkyl, hydroxy, alkoxy, haloalkyl, nitro, amino, acylamino, alkylthio, alkylsulphinyl or alkylsulphonyl: R8 represents a group of the formula -(CH2)p-R9 or -(CH2)q-R10: R9 represents hydrogen, alkylcarbonyl, aminoalkylcarbonyl, cyano, amidino, alkoxycarbonyl, aryloxycarbonyl, alkylsulphonyl, aminocarbonyl or aminothiocarbonyl; R10 represents hydroxy, alkoxy, halogen, amino, monoalkylamino, dialkylamino, trialkylamino, azido, acylamino, alkylsulphonylamino, arylsulphonylamino, alkylthio, alkoxycarbonylamino, aminoacylamino, aminocarbonylamino, isothiocyanato, alkylcarbonyloxy, alkylsulphonyloxy or arylsulphonyloxy, a 5- or 6-membered saturated nitrogen-containing heterocycle attached via the nitrogen atom or a group of the formula -U-C(V)-W: U represents S or NH; V represents NH, NNO2, NCN, CHNO2: W represents amino, monoalkylamino or dialkylamino: one of X and Y represents O and the other represents O or (H,H); Z represents CH or N: m stands for 0-5, with the proviso that m stands for 2-5 when Z represents N: n stands for 1-5: p stands for 0-5: and q stands for 0-5, with the proviso that q stands for 2-5 when Z stands for N; as well as pharmaceutically acceptable salts of acidic compounds of formula I with bases and of basic compounds of formula I with acids, are useful in the control or prevention of inflammatory, immunological, oncological. bronchopulmonary or cardiovascular disorders or for the treatment of asthma or AIDS. They can be prepared from correspondingly substituted furandiones.

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