Methods for targeting cells that express fibroblast growth...

Details Methods for targeting cells that express fibroblast growth... Methods for targeting cells that express fibroblast growth...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 47/48 (2006.01) C07K 14/50 (2006.01) C12N 15/19 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2393200

Fibroblast growth factor-18 (FGF-18) binds with FGF receptors-2 and -3. Compositions comprising an FGF-18 component can be used to target cells that express these receptors. Suitable targets include tumor cells that express constitutively activated forms of FGF receptors-2 and -3.

Selon l'invention, le facteur de croissance des fibroblastes-18 (FGF-18) se lie avec les récepteurs 2 et 3 du FGF. Des compositions comprenant un composant FGF-18 peuvent être utilisées pour cibler les cellules exprimant ces récepteurs. Parmi les cibles appropriées, les cellules tumorales exprimant de manière consécutive des formes activées des récepteurs 2 et 3 du FGF.

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