Perilipin as a target for regulation of body weight, muscle...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/00 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2425789

The present invention relates to screening assays to identify compounds that modulate the activity or expression of perilipin. The present invention also relates to methods and therapeutic compositions for the prevention or treatment of body weight disorders or diabetes comprising administering to subjects compounds that modulate the activity or expression of perilipin. In one aspect, the invention of perilipin in order to treat and/or prevent obesity or diabetes, and to enhance lipid metabolism and muscle mass. In another aspect, the invention relates to methods and compositions that agonize the activity of perilipin in order to enhance lipid accumulation in a subject in order to increase weight gain.

La présente invention concerne des techniques de criblage permettant d'identifier des composés qui modulent l'activité ou l'expression de la périlipine. L'invention traite également de méthodes et de compositions thérapeutiques visant à prévenir ou à traiter les problèmes de poids ou le diabète, et consistant à administrer aux sujets des composés qui modulent l'activité ou l'expression de la périlipine. Dans un mode de réalisation, l'invention traite de méthodes et compositions qui ont un effet antagoniste sur l'activité ou l'expression de la périlipine afin de traiter et/ou prévenir l'obésité ou le diabète, et de renforcer le métabolisme lipidique de même que la masse musculaire. Dans un autre mode de réalisation, l'invention a trait à des méthodes et compositions qui ont un effet agoniste sur l'activité de la périlipine afin de renforcer l'accumulation des lipides chez un sujet dans le but d'augmenter le gain pondéral.

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