Expression and export of anti-obesity proteins as fc fusion...

Details Expression and export of anti-obesity proteins as fc fusion... Expression and export of anti-obesity proteins as fc fusion...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/22 (2006.01) A61K 48/00 (2006.01) A61P 3/04 (2006.01) C07K 14/575 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/16 (2006.01)

Patent

CA 2356401

Disclosed are nucleotide sequences, for example, DNA or RNA sequences, which encode an immunoglobulin Fc-Leptin fusion protein. The nucleotide sequences can be inserted into a suitable expression vector and expressed in mammalian cells. Also disclosed is a family of immunoglobulin Fc-Leptin fusion proteins that can be produced by expression of such nucleotide sequences. Also disclosed are methods using such nucleotide sequences and fusion proteins for treating conditions which are alleviated by the administration of leptin.

L'invention concerne des séquences nucléotidiques, par exemple des séquences d'ADN ou d'ARN, codant une protéine hybride leptine-Fc immunoglobuline. Ces séquences nucléotidiques peuvent être insérées dans un vecteur d'expression adapté et exprimées dans des cellules mammaliennes. L'invention concerne aussi des techniques utilisant ces séquences nucléotidiques et ces protéines hybride dans le traitement de pathologies que l'administration de leptine atténue.

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