Insect neuropeptides

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/53 (2006.01) A01N 63/02 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2183568

Novel peptides isolated from the blowfly Calliphora vomitoria are related to the allatostatin class of insect neuropeptides, and have inhibitory effects on gut motility in the blowfly C. vomitoria and allatostatic effects in cockroaches of the species Diploptera punctata and Periplaneta americana. The peptides have novel sequences containing hydoxyproline residues and C-terminal amide groups which give the peptides improved stability in the gut of the insects.

De nouveaux peptides isolés de la lucilie Calliphora vomitoria sont apparentés à la classe des allatostatines des neuropeptides d'insectes, et inhibent la motilité du tube digestif de la lucilie C. vomitoria tout en produisant des effets allatostatiques chez les blattes de l'espèce Diploptera punctata et Periplaneta americana. Ces peptides comprennent de nouvelles séquences contenant des restes hydroxyproline et des groupes amides C-terminaux qui leur confèrent une stabilité améliorée dans le tube digestif des insectes.

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