A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/08 (2006.01) A61K 31/704 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 14/485 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2451993
The inventive polypeptide is embodied in the form of a similar fragment of the epidermal growth factor of aminoacid ranging from 21 to 31 and capable of efficiently binding with the receptor of the epidermal growth factor as a vector for the directed supply of anticancer agents to tumour cells. The inventive conjugate of said polypeptide contains doxorubicine and has a selective action on cancer tumours and can substantially reduce the resistance of the tumour cells with respect to the anticancer agents, the conjugated parts of said agents being binded with the aid of a chemical bond which is unstable in relation to acid hydrolysis. The inventive pharmaceutical composition comprises an efficient quantity of conjugate and a carrier which is fit for intravenous injection. Said invention can be used for medicine for treating cancer patients.
L'invention concerne un polypeptide qui représente un analogue du fragment du facteur de croissance épidermique de l'acide amine 21 à 31, capable de se lier efficacement au récepteur du facteur de croissance épidermique et pouvant s'utiliser comme vecteur de transport ciblé des médicaments anti-tumoraux jusqu'aux cellules tumorales. L'invention concerne aussi un conjugué de polypeptide avec doxorubicine possédant une action sélective vis-à-vis des tumeurs cancéreuses, qui est capable de réduire sensiblement la résistance des cellules cancéreuses aux médicaments anti-tumoraux dans lequel les parties conjuguées sont reliées par une liaison chimique non résistant à l'hydrolyse acide. La composition pharmaceutique contient une composition efficace de conjugué et un support adapté à l'injection intraveineuse. L'invention peut s'utiliser en médecine pour traiter les patients oncologiques.
Feldman Natalya Borisovna
Kiselev Sergey Michailovich
Lutsenko Sergey Viktorovich
Severin Evgeniy Sergeevich
Severin Sergey Evgenyevich
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Zakrytoe Aktsionernoe Obschestvo "russkie Biotechnologii"
LandOfFree
Polypeptide, its conjugate with doxorubicin and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polypeptide, its conjugate with doxorubicin and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polypeptide, its conjugate with doxorubicin and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1918084