A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 15/40 (2006.01) A61L 27/44 (2006.01)
Patent
CA 2634316
Disclosed herein is a biological wound dressing having good biocompatibility, durable flexibility, that is gas permeable but impenetrable to bacteria, that is convenient to use, and a method of preparation thereof. The biological wound dressing comprises a substrate prepared from animal tissue. The dressing is made by a method comprising: crosslinking and fixing the substrate with a non-aldehyde fixative; minimizing antigens from the substrate; and incorporating an active layer in the substrate. Minimizing the antigens from the substrate comprises: utilizing a first reagent selected from low molecular weight organic acid anhydride, acyl chloride, acylamide, or monocyclic oxide, to block one or more antigen determinants of the substrate; and utilizing a second reagent, being a guanidine compound, to replace hydrogen bonding in the spiral chains of the protein molecules in the substrate and alter its specific conformation.
La présente invention concerne un pansement biologique produit au moyen d'un procédé qui consiste à disposer d'un tissu animal naturel présentant un substrat (1), à réticuler et à fixer le substrat (1), à minimiser les antigènes provenant du substrat (1), puis à intégrer une couche active (2) dans le substrat (1).
Miltons Ip/p.i.
Summit(gd) Biotech Co. Ltd
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