Tricyclic monosaccharide derivatives useful in treating...

Details Tricyclic monosaccharide derivatives useful in treating... Tricyclic monosaccharide derivatives useful in treating...

A - Human Necessities

61

K

A61K 31/7048 (2006.01) A61K 31/357 (2006.01) A61K 31/39 (2006.01) A61K 31/70 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01) C07H 9/04 (2006.01) C07H 11/00 (2006.01)

Patent

CA 2380208

Anticonvulsant compounds of general formula (I) where X, R1, R2, R3, R4, R5, and R6 are as herein defined; are useful in treating acute ischemia-induced neurodegeneration, such as occurs during and after stroke, head trauma, spinal injury, non-fatal cardiac arrest, or major surgical procedures. Furthermore, pharmaceutical compositions containing a compound of formula (I) as well as methods for their use are disclosed.

L'invention porte sur des composés anticonvulsifs de la formule générale (I) dans laquelle X, R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, et R¿6? sont tels que définis dans la demande. Ces composés sont utiles dans le traitement des maladies neurodégénératives induites par l'ischémie aiguë, comme cela se produit au cours d'une attaque ou après une attaque, un traumatisme crânien, des lésions de la colonne vertébrale, des arrêts cardiaques non fatals ou des interventions chirurgicales majeures. D'autre part, l'invention porte sur des compositions pharmaceutiques contenant un composé de la formule (I) ainsi que sur leurs procédés d'utilisation.

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