Peptide diagnostics and therapeutics for spondyloarthropathies

Details Peptide diagnostics and therapeutics for spondyloarthropathies Peptide diagnostics and therapeutics for spondyloarthropathies

C - Chemistry, Metallurgy

12

N

C12N 9/00 (2006.01) A61K 39/02 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/195 (2006.01) C07K 14/74 (2006.01) C07K 17/00 (2006.01) G01N 33/569 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2143322

It has been determined that HLA B27 is related to proteins of Gram negative enteric bacteria. The proteins from enteric organisms that share sequence with B27 tend to have sequences that satisfy protein sequence motifs which are thought to predict binding to B27. These sequences (i.e. peptides) are useful for diagnostic and therapeutic purposes and can be used to design additional peptides from Gram negative enteric bacteria which are important for spondyloarthropathies. These peptides can be used to screen for antibodies and T cells which are indicative of spondyloarthropathies. The peptides alone or in conjunction with Beta2 microglobulin or soluble HLA molecules can be used to produce tolerance.

Il a été établi que l'allèle HLA B27 est relié à des protéines de bactéries entériques Gram négatif. Les protéines d'organismes entériques qui partagent une séquence avec l'allèle B27 ont tendance à avoir des séquences qui répondent aux motifs structuraux des protéines qui, pense-t-on, prévoient la liaison avec l'allèle B27. Ces séquences (c.-à-d., les peptides) servent pour le diagnostic et la thérapie et peuvent être utilisées pour concevoir d'autres peptides de bactéries entériques Gram négatif qui jouent un rôle important dans les spondyloarthropathies. Ces peptides peuvent servir à détecter des anticorps et des cellules T révélateurs de spondyloarthropathies. Seuls ou en association avec de la microglobuline Beta2 ou des molécules HLA solubles, ils peuvent aussi être utilisés pour produire de la tolérance.

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