C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/36 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) A61P 43/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 14/52 (2006.01) C07K 14/745 (2006.01) C07K 16/18 (2006.01) C07K 16/22 (2006.01) C07K 16/24 (2006.01) C07K 16/36 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2160591
The present invention relates to thrombopoietin (TPO) polypeptides having the biological activity of specifically stimulating or increasing platelet production comprising the amino acid sequence 1-332 of SEQ ID NO: 6 or a derivative thereof, DNA molecules encoding TPO polypeptides, processes for production of the polypeptides, antibodies specifically immunoreactive with the polypeptides, pharmaceutical compositions comprising the polypeptides, and methods for using the polypeptides in treatment of platelet disorders such as thrombocytopenia.
La présente invention porte sur des polypeptides de TPO ayant une activité biologique spécifique de stimulation ou d'accroissement de la production de plaquettes contenant la séquence d'aminoacides 1-332 de NO ID SEQ: 6 ou un dérivé, sur des molécules d'ADN codant des polypeptides de TPO, sur les procédés de production de ces polypeptides, sur des anticorps spécifiquement immunoréactifs vis-à-vis de ces polypeptides, sur des compositions pharmaceutiques contenant ces polypeptides, et sur les applications de ces polypeptides dans le traitement d'anomalies plaquettaires comme la thrombopénie.
Akahori Hiromichi
Iwamatsu Akihiro
Kato Takashi
Kuroki Ryota
Miyazaki Hiroshi
Kirin Brewery Company Limited
Ridout & Maybee Llp
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