C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/40 (2006.01) A61K 31/664 (2006.01) A61K 31/665 (2006.01) C07C 59/64 (2006.01) C07F 9/44 (2006.01) C07F 9/58 (2006.01) C07F 9/6574 (2006.01)
Patent
CA 2546601
The present invention relates to compounds of phosphonic acid containing T3 mimetics, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndromex and diabetes.
L'invention concerne des composés d'acide phosphonique contenant des substances mimétiques T3, des stéréoisomères, des sels pharmaceutiquement acceptables, des cocristaux et des promédicaments de ces éléments, ainsi que des sels pharmaceutiquement acceptables et des cocristaux de ces promédicaments. La présente invention porte également sur leur préparation et leurs utilisations pour prévenir et/ou traiter des troubles du métabolisme tels que l'obésité, le NASH, l'hypercholestérolémie et l'hyperlipidémie, ainsi que des troubles associés comme l'athérosclérose, l'insuffisance coronaire, la diminution de la tolérance au glucose, le syndrome X métabolique et le diabète.
Boyer Serge H.
Erion Mark D.
Jiang Hongjian
Metabasis Therapeutics Inc.
Smart & Biggar
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