Mitotic kinesin inhibitors

Details Mitotic kinesin inhibitors Mitotic kinesin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 231/06 (2006.01) A61K 31/415 (2006.01)

Patent

CA 2602146

The present invention relates to fluorinated dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

La présente invention concerne des composés dihydropyrazole fluorés qui conviennent pour traiter des maladies prolifératives cellulaires, pour traiter des pathologies associées à l'activité kinésine KSP et pour inhiber la kinésine KSP. Cette invention concerne aussi des compositions comprenant ces composés et des techniques d'utilisation de celles-ci pour traiter un cancer chez des mammifères.

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