Methods for making and breaking prions (prpsc) produced from...

Details Methods for making and breaking prions (prpsc) produced from... Methods for making and breaking prions (prpsc) produced from...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 39/395 (2006.01) C07K 7/08 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C12P 21/06 (2006.01) G01N 33/536 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2430835

Agents for making and breaking prions (PrP Sc) under "physiological" conditions, in vitro, are revealed. These include a synthetic copy of a domain of a bovine/ovine naturally occurring protein ("cf22aa") that converts constitutive native human brain prion proteins (PrPC) to (PrP Sc), the other, a synthetic copy of a domain of a protein encoded on the anti-sense strand of human P53 gene, ("pbf13aa") breaks-up PrP from TSE infected human brains, and PrP Sc artificially added to human blood and other fluids. Also revealed are two mono-specific antibodies which block conversion, to PrP Sc and remove excess of pbf13aa from fluids treated with this polypeptide, respectively.

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