A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 9/08 (2006.01) A61K 47/18 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2708627
A stable solution preparation containing an antibody, which is characterized by containing arginine and methionine, is provided as a stable antibody-containing preparation suitable for subcutaneous administration wherein dimer formation and deamidation are prevented during prolonged storage.
L'invention porte sur la préparation d'une solution stable contenant un anticorps, caractérisée en ce qu'elle contient de l'arginine et de la méthionine. La solution fournit un anticorps stable approprié pour une administration sous-cutanée, mais dans laquelle la formation d'un dimère et la déamidation est prévenue pendant un stockage prolongé.
Imaeda Yoshimi
Kameoka Daisuke
Maeda Terutoshi
Morichika Toshiyuki
Stauch Oliver Boris
Chugai Seiyaku Kabushiki Kaisha
F. Hoffmann-La Roche Ag
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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