Process for the preparation of pregnanes

Details Process for the preparation of pregnanes Process for the preparation of pregnanes

C - Chemistry, Metallurgy

07

J

C07J 71/00 (2006.01) C07J 75/00 (2006.01) C07J 5/00 (2006.01)

Patent

CA 2509366

An improved stereoselective process for the preparation of 6.alpha.- fluoropregnane derivatives of formula (I), comprising the reaction of 3- benzoyloxy-.DELTA.3,5-pregnane derivatives of formula (II), with an electrophilic fluorination agent in a substantially water-free reaction mixture and in the presence of a salt of a strong acid with a nitrogenous base.

La présente invention a trait à un procédé stéréosélectif amélioré pour la préparation de dérivés de 6.alpha.-fluoropregnane de formule (I), comprenant la réaction de dérivés de 3-benzoyloxy-?3,5-pregnane de formule (II), avec un agent de fluoration électrophile dans un mélange réactionnel exempt d'eau et en présence d'un sel d'un acide fort avec une base azotée.

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