Modified nucleotides and methods useful for nucleic acid...

Details Modified nucleotides and methods useful for nucleic acid... Modified nucleotides and methods useful for nucleic acid...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2325399

The present invention relates to a method for sequencing nucleic acids. In particular, such method includes incorporating certain modified nucleotides referred to as Simtides into nucleic acid strands. These Simtides are complexes comprising a nucleotide base (or analog thereof), a linker, and a label capable of generating a detectable signal for sequencing. A Simtide may be incorporated into a sequencing fragment as a primer component, as a chain elongator, or as a chain terminator.

La présente invention concerne une méthode de séquençage d'acides nucléiques. En particulier, cette méthode consiste à incorporer certains nucléotides modifiés appelés Simtides dans des brins d'acides nucléiques. Ces Simtides sont des complexes comprenant une base nucléotidique (ou analogue de celle-ci), un lieur, ainsi qu'une marque capable de produire un signal détectable pour le séquençage. Un Simtide peut être incorporé dans un fragment de séquençage en tant que constituant d'amorce, et un prolongateur de chaîne, ou un terminateur de chaîne.

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