Novel peptides and methods for the treatment of inflammatory...

Details Novel peptides and methods for the treatment of inflammatory... Novel peptides and methods for the treatment of inflammatory...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61P 29/00 (2006.01) C07K 7/08 (2006.01)

Patent

CA 2579547

The invention relates to an isolated peptides comprising at least the amino acid sequence YDRREY or a derivative thereof, nucleic acids encoding the peptides, pharmaceutical compositions and methods for modulating ~ 7 integrin function, including methods for treatment of inflammatory disorders, antibodies directed to said peptides and methods for identification of integrin ~ 7 functional interactors.

La présente invention concerne des peptides isolés comprenant au moins la séquence d'acides aminés YDRREY ou l'un de ses dérivés, des acides nucléiques codant les peptides, des compositions pharmaceutiques et des procédés pour moduler la fonction de l'intégrine .beta.7, y-compris des procédés pour le traitement de troubles inflammatoires, des anticorps dirigés contre ces peptides, et des procédés pour l'identification d'interacteurs fonctionnels de l'intégrine .beta.7.

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