A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/76 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) A61N 5/10 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2234060
The present invention is directed to novel methods of enhancing the effectiveness of DNA damaging agents by exposing cells to viruses prior to or during exposure to the damaging agent. In certain embodiments of the invention, the DNA damaging agent is ionizing radiation, the virus is an adenovirus, and the increase in cell killing is synergistic when compared to radiation alone.
La présente invention concerne de nouveaux procédés visant à améliorer l'efficacité des agents détériorant l'ADN et consistant à exposer les cellules à des virus avant ou pendant l'exposition à l'agent détériorant. Dans certaines formes d'exécution de l'invention, l'agent détériorant l'ADN est un rayonnement ionisant, le virus est un adénovirus, et cette synergie permet une élimination plus efficace des cellules par rapport à celle obtenue uniquement par rayonnement.
Hallahan Dennis E.
Kufe Donald
Roizman Bernard
Sibley Gregory S.
Weichselbaum Ralph R.
Arch Development Corporation
Dana-Farber Cancer Institute
Kirby Eades Gale Baker
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