C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) A61K 31/695 (2006.01) C07D 401/06 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2198084
The present invention relates to novel substituted piperidine derivatives of formula (1), stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic diseases including: seasonal rhinitis, allergic rhinitis, and sinusitis.
La présente invention concerne de nouveaux dérivés de pipéridine substitués de la formule (1), ainsi que leurs stéréo-isomères et leurs sels acceptables sur le plan pharmaceutique, qui sont utiles comme antagonistes des récepteurs à l'histamine et comme antagonistes des récepteurs à la tachykinine. Ces antagonistes sont utiles pour le traitement d'affections allergiques telles que les rhinites saisonnières, les rhinites allergiques et les sinusites.
Bratton Larry D.
Burkholder Timothy P.
Kane John M.
Kudlacz Elizabeth M.
Maynard George D.
Merrell Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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