Use of an adenosine a3 receptor agonist for inhibition of...

A - Human Necessities – 61 – K

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A61K 31/7076 (2006.01) A61K 31/52 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2434906

The present invention concerns the use of an active ingredient selected from the group consisting of agonists of the adenosine receptor system, for inhibiting viral replication in cells. In particular, the invention provides a composition and method for inhibiting viral replication in cells, the method comprising presenting to the cells an effective amount of the active ingredient. According to one embodiment, the adenosine agonist is an A3 receptor agonist (A3RAg). The invention is particularly useful, for although not limited to, inhibiting the replication of HIV virus in human cells.

L'invention concerne l'utilisation d'un principe actif sélectionné parmi le groupe comprenant des agonistes du système récepteur de l'adénosine, afin d'inhiber la réplication virale dans des cellules. Elle concerne, en particulier, une composition et une méthode d'inhibition de la réplication virale dans des cellules, la méthode consistant à présenter aux cellules une quantité efficace du principe actif. Selon une réalisation, l'agoniste d'adénosine est un agoniste du récepteur A3 (A3RAg). Quoique sans être limitée à cette application, l'invention est particulièrement utile pour inhiber la réplication du virus VIH dans des cellules humaines.

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