C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2367334
The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumer cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
L'invention concerne des compositions et des procédés pour le diagnostic et le traitement de la croissance et de la prolifération de cellules néoplasiques chez les mammifères dont les humains. Les procédés de l'invention consistent à identifier les gènes qui sont amplifiés dans le génome de cellules tumorales. On suppose que ladite amplification génique est associée à la surexpression du produit génique par rapport aux cellules normales du même type de tissu et qu'elle contribue à la tumorigénèse. Ainsi, on a constaté que les protéines codées par les gènes amplifiés sont des cibles utiles pour le diagnostic et/ou le traitement (dont la prévention) de certains cancers, et peuvent agir en tant que prédicteurs du pronostic du traitement des tumeurs. L'invention se rapporte à des nouveaux polypeptides et à des molécules nucléotidiques codant lesdits polypeptides ainsi qu'à des vecteurs et à des cellules hôtes comprenant lesdites séquences nucléotidiques, à des molécules polypeptidiques chimères comprenant les polypeptides de l'invention fusionnés à des séquences polypeptidiques hétérologues, à des anticorps qui se lient aux polypeptides de l'invention et à des procédés de production des polypeptides de l'invention.
Botstein David
Goddard Audrey
Gurney Austin L.
Roy Margaret Ann
Watanabe Colin K.
Dennison Associates
Genentech Inc.
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