Substituted piperidines as ccr3 antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/04 (2006.01) A61K 31/4523 (2006.01) A61K 31/454 (2006.01) C07D 401/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2753151

Object of the present invention are novel substituted compounds of the formula 1, wherein A, R1, R2, R3 and R4 are defined as in the description. Another object of the present invention is to provide antagonists of CCR3, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically accept- able salt thereof.

La présente invention concerne de nouveaux composés substitués de formule 1, dans laquelle A, R1, R2, R3 et R4 sont tels que définis dans la description. La présente invention concerne également des antagonistes de CCR3, plus particulièrement des compositions pharmaceutiques comprenant un vecteur pharmaceutiquement acceptable et une quantité thérapeutiquement efficace d'au moins l'un des composés de la présente invention ou de son sel pharmaceutiquement acceptable.

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