Caspase activated prodrugs therapy

Details Caspase activated prodrugs therapy Caspase activated prodrugs therapy

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2399255

The invention provides novel methods for the localized delivery of pharmaceutical agents by the administration of a caspase conjugate that targets a cell type of interest and the additional administration of a pro- agent that is locally converted, in the presence of the caspase, to an active agent. The invention further provides novel tageting agents comprising a caspase as well as novel prodrugs comprising a caspase cleavable prodrug moiety. The invention also provides pharmaceutical compositions as well as methods of treatment comprising the caspase conjugates and prodrugs of the invention

L'invention concerne de nouvelles techniques permettant l'administration locale d'agents pharmaceutiques au moyen de l'administration d'un conjugué de caspase ciblant un type de cellule recherché et par l'administration supplémentaire d'un pro-agent transformé localement en agent actif en présence de caspase. L'invention concerne également de nouveaux agents de ciblage comprenant une caspase ainsi que de nouveaux promédicaments contenant un groupe fonctionnel promédicament pouvant être clivé par une caspase. L'invention concerne en outre des compositions pharmaceutiques ainsi que des méthodes de traitement comprenant les conjugués de caspase et les promédicaments de l'invention.

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