C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) C12N 15/11 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2548567
Antihuman Mpl antibody is obtained and purified. By using a genetic engineering technique, antihuman Mpl diabody and antihuman Mpl sc(Fv)2 are purified. Furthermore, the antihuman Mpl sc(Fv)2 is successfully humanized. As the results of the evaluation on the TPO-like agonistic activities of the diabody and the sc(Fv)2, it is found out that the diabody and the sc(Fv)2 show high agonistic activities to antihuman Mpl antibody and their activities are comparable or even superior to the activity of human TPO which is a natural ligand.
L'invention concerne un anticorps anti Mpl humain que l'on produit et purifie. Le fragment d'anticorps dimérique (diabody) anti Mpl humain ainsi que le fragment sc(Fv)2 anti Mpl humain sont purifiés au moyen d'une technique de génie génétique. De plus, le fragment sc(Fv)2 anti Mpl humain est humanisé avec succès. L'évaluation des activités agonistes de type TPO du diabody et du fragment sc(Fv)2 montre qu'elles sont élevées vis-à-vis de l'anticorps anti Mpl humain, et ces activités sont comparables à l'activité de la TPO humaine, qui est un ligand naturel, voire plus élevées que celle-ci.
Hirata Yuichi
Nakano Kiyotaka
Orita Tetsuro
Tsuchiya Masayuki
Tsunoda Hiroyuki
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Chugai Seiyaku Kabushiki Kaisha
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