Human dnase resistant to actin inhibition

Details Human dnase resistant to actin inhibition Human dnase resistant to actin inhibition

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 38/46 (2006.01) A61P 11/00 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 9/16 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2242562

This invention relates to a novel human deoxyribonuclease, referred to as LS- DNase, that is relatively resistant to inhibition by actin, as compared to human DNase I. The invention provides nucleic acid sequences encoding LS-DNase, thereby enabling the production of LS-DNase by recombinant DNA methods in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic uses of LS-DNase.

Cette invention concerne une nouvelle désoxyribonucléase humaine, appelée LS-DNase, qui est relativement résistante à l'inhibition par l'actine, en comparaison avec la LS-DNase I humaine. L'invention concerne des séquences d'acides nucléiques codant la LS-DNase, afin de produire LS-DNase par des méthodes ayant recours à l'ADN recombinant dans des quantités suffisantes pour en faire une utilisation clinique. L'invention concerne également des compositions pharmaceutiques ainsi que les utilisations thérapeutiques de LS-DNase.

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