Matrix metalloproteinase 11 vaccine

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/435 (2006.01) A61K 39/00 (2006.01) C07K 19/00 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2623531

Compositions comprising matrix metalloproteinase 11 (MMP-11) or stromelysin-3 (ST-3) or the nucleic acid encoding the MMP-11 for use in vaccines for treating tumors and cancers, which overexpress MMP-11, are described. In particular embodiments, the compositions comprise a nucleic acid encoding a fusion polypeptide that includes the catalytically inactivated MMP-11 linked at the C-terminus to an immunoenhancing element wherein the codons encoding the MMP-11 and the immunoenhancing element have been optimized for enhanced expression of the fusion polypeptide in human cells. In other embodiments, the compositions comprise the catalytically inactivated MMP-11 linked at the C- terminus to an immunoenhancing element. The compositions can be used alone or in synergy with vaccines against other tumor associated antigens as well as with conventional therapies such as radiation therapy and chemotherapy.

L'invention porte sur des compositions de métalloprotéinase 11 matricielle (MMP-11) ou de stromélysine-3 (ST-3) ou de l'acide nucléique codant pour la MMP-11 en tant que vaccins de traitement de tumeurs et de traitements surexprimant la MMP-11. Dans des exécutions particulières, les compositions comprennent un acide nucléique codant pour un polypeptide de fusion incluant la MMP-11 inactivée par catalyse et fixée par son terminus C à un élément renforceur d'immunité, les codons codant pour la MMP-11 et l'élément renforceur d'immunité ayant été optimisés pour accroître l'expression de polypeptides de fusion dans des cellules humaines. Dans d'autres exécutions, les compositions comprennent la MMP-11 inactivée par catalyse liée par son terminus C à un élément renforceur d'immunité. Les compositions peuvent s'utiliser seules ou avec des vaccins contre d'autres antigènes associés à des tumeurs ainsi qu'à des thérapies classiques de radiothérapie et de chimiothérapie.

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