Aortic preferentially-expressed gene and uses thereof

Details Aortic preferentially-expressed gene and uses thereof Aortic preferentially-expressed gene and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2226085

An aortic-preferentially-expressed gene-1 (APEG-1) polypeptide, DNA sequences encoding and controlling the transcription of APEG-1, methods of diagnosing vascular injury, and methods of inhibiting vascular smooth muscle cell proliferation by increasing the level of APEG-1 at the site of vascular injury.

L'invention se rapporte à un polypeptide du gène à expression spécifique des cellules aortiques-1 (APEG-1), à des séquences d'ADN codant et régulant la transcription d'APEG-1, à des procédés de diagnostic de lésions vasculaires et à des procédés d'inhibition de la prolifération cellulaire dans les muscles lisses vasculaires, consistant à augmenter le taux d'APEG-1 sur le site de la lésion vasculaire.

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