Process for the optical resolution and recycling of tomoxetine

Details Process for the optical resolution and recycling of tomoxetine Process for the optical resolution and recycling of tomoxetine

C - Chemistry, Metallurgy

07

C

C07C 213/06 (2006.01) C07C 213/10 (2006.01) C07C 217/48 (2006.01)

Patent

CA 2561866

The present invention provides a process for the optical resolution of racemic tomoxetine under reaction conditions that improve reaction yields and optical purity. The invention also provides an epimerization process for the (S)-(+) enantiomer. The invention further provides the conversion of the enantiomer obtained from the optical resolution into atomoxetine or a pharmaceutically acceptable salt thereof.

La présente invention concerne un procédé de fabrication pour la résolution optique d'une tomoxétine racémique en conditions de réactions qui permettent d'améliorer le rendement de la réaction et la pureté optique. L'invention concerne également un procédé d'épimérisation pour l'énantiomère (S)-(+). L'invention concerne en outre la conversion de l'énantiomère, obtenue à partir de la résolution optique, en atomoxétine ou un sel pharmaceutiquement acceptable de cette dernière.

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