Quinoline leukotriene antagonists

Details Quinoline leukotriene antagonists Quinoline leukotriene antagonists

C - Chemistry, Metallurgy

07

D

C07D 215/18 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2283101

Compounds of formula (I) are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

La présente invention concerne des composés répondant à la formule (1), qui sont des antagonistes de l'action des leucotriènes. Ces composés sont utiles en tant qu'agents antiasthmatiques, antiallergiques, antiinflammatoires et cytoprotecteurs. Il peuvent également servir à traiter l'angine, les spasmes cérébraux, la glomérulonéphrite, l'hépatite, l'endotoxémie, l'uvéite et le rejet de greffe allogénique.

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