Isoquinoline modulators of atp-binding cassette transporters

Details Isoquinoline modulators of atp-binding cassette transporters Isoquinoline modulators of atp-binding cassette transporters

C - Chemistry, Metallurgy

07

D

C07D 217/22 (2006.01) A61K 31/472 (2006.01) A61K 31/4725 (2006.01) A61P 11/00 (2006.01) C07D 401/04 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2705562

Compounds of the present invention, of formula (I) and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

L'invention concerne des composés, de la formule (I) : et des compositions pharmaceutiquement acceptables de ceux-ci, qui sont utiles en tant que modulateurs de transporteurs de cassette de liaison à l'ATP ("ABC") ou des fragments de ceux-ci, y compris un régulateur de la conductance transmembranaire de la fibrose kystique ("CFTR"). La présente invention concerne également des procédés de traitement de maladies modérées par transporteur d'ABC en utilisant des composés de la présente invention.

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