Specifically beta-beta cross-linked hemoglobins and method...

Details Specifically beta-beta cross-linked hemoglobins and method... Specifically beta-beta cross-linked hemoglobins and method...

C - Chemistry, Metallurgy

07

K

C07K 14/805 (2006.01) A61K 35/14 (2006.01) A61K 38/42 (2006.01)

Patent

CA 2111092

A modified hemoglobin comprising hemoglobin which is cross-linked with a cross-linking reagent. The cross-linking rea- gent comprises an aromatic- or aliphatic-derived acyl material having at least two anionic leaving groups, each of them being ad- jacent to an electrophile group. Such agent provides a cross-link between the beta-chains within the 2,3-diphosphoglycerate bind- ing site with a linkage distance between the beta-chains of about 5 to 9 angstroms. A method of preparing the modified hemoglobin and its use as a blood substitute or a plasma expander are also described.

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