Pyrazine derivatives as epithelial sodium channel blocker

Details Pyrazine derivatives as epithelial sodium channel blocker Pyrazine derivatives as epithelial sodium channel blocker

C - Chemistry, Metallurgy

07

D

C07D 241/32 (2006.01) A61K 31/4965 (2006.01) A61K 31/497 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 403/12 (2006.01) C07D 451/04 (2006.01)

Patent

CA 2630889

A compound of formula (I) or tautomers, or stereoisomers, or solvates, or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, T, L, W, X, Y and A are as defined herein for the for treatment of conditions mediated by the blockade of an epithelial sodium channel, particularly an inflammatory or allergic condition.

La présente invention concerne un composé de formule (I) ou des tautomères, ou stéréoisomères, ou solvates, ou des sels pharmaceutiquement acceptables de ceux-ci, dans laquelle R1, R2, R3, R4, R5, T, L, W, X, Y et A sont tels que définis dans la description pour le traitement de conditions liées au blocage du canal sodique épithélial, notamment une pathologie inflammatoire ou allergique.

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