Compositions with hematopoietic and immune activity

A - Human Necessities – 61 – K

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A61K 38/18 (2006.01)

Patent

CA 2515288

The present invention provides methods of using Bv8 and EG-VEGF polypeptides and nucleic acids to promote hematopoiesis. Also provided herein are methods of screening for modulators of Bv8 and EG-VEGF activity. Furthermore, methods of treatment using Bv8 and EG-VEGF polypeptides or Bv8 and EG-VEGF antagonists are provided.

La présente invention a trait à des procédés d'utilisation de polypeptides et d'acides nucléiques de Bv8 et du facteur de croissance endothéliale vasculaire dérivé de la glande endoctrine pour favoriser l'hématopoïèse. L'invention a également trait à des procédés de criblage pour des modulateurs de l'activité de Bv8 et du facteur de croissance endothéliale vasculaire dérivé de la glande endocrine. En outre, l'invention a trait à des procédés de traitement utilisant des polypeptides de Bv8 et du facteur de croissance endothéliale vasculaire dérivé de la glande endocrine ou d'antagonistes de Bv8 et du facteur de croissance endothéliale vasculaire dérivé de la glande endocrine.

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