Substituted tetrahydropyrroloquinoline derivatives as kinase...

Details Substituted tetrahydropyrroloquinoline derivatives as kinase... Substituted tetrahydropyrroloquinoline derivatives as kinase...

C - Chemistry, Metallurgy

07

D

C07D 471/06 (2006.01) A61K 31/437 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) A61P 37/02 (2006.01)

Patent

CA 2600630

Disclosed is a compound of formula (I), wherein X, R1, R2, and R3 have the meanings indicated in claim 1. Said compounds are tyrosine kinase inhibitors, particularly TIE-2 kinase inhibitors, as well as Raf kinase inhibitors and can be used for the treatment of tumors, among other things.

La présente invention concerne des composés de formule (I) dans laquelle X, R1, R2 et R3 ont les significations énoncées dans la revendication 1. Ces composés sont des inhibiteurs des tyrosine kinases, en particulier des TIE-2, et des Raf-kinases et peuvent être utilisées entre autres pour traiter des tumeurs.

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