P53 binding t cell receptor molecules and uses thereof

Details P53 binding t cell receptor molecules and uses thereof P53 binding t cell receptor molecules and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/725 (2006.01) C12Q 1/02 (2006.01) G01N 33/567 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2487779

The invention provides T-cell receptor (TCR) molecules that bind peptides derived from the p53 protein, preferably, the human p53 protein. The TCR molecules include both heterodimeric molecules and single chain molecules which specifically bind a sequence preferably spanning about amino acid positions 264 to 272 of the p53 protein displayed in the context of an HLA molecule, preferably, HLA-A2.1. Also disclosed are methods for making and using such TCR molecules. The invention has a wide spectrum of useful applications including therapeutic uses and use in the detection of cells expressing p53 protein.

L'invention concerne des molécules du récepteur des lymphocytes T (TCR), qui se lient aux peptides dérivés de la protéine p53, de préférence la protéine p53 humaine. Les molécules TCR comprennent tant des molécules hétérodimériques que des molécules monocaténaires, qui se lient de manière spécifique à une séquence recouvrant, de préférence, presque les positions 264 à 272 des acides aminés de la protéine p53 présentée en rapport avec une molécule HLA, de préférence HLA-A2.1. L'invention concerne en outre des méthodes de production et d'utilisation de molécules TCR. Les molécules de l'invention répondent à un large éventail d'applications utiles, y compris des utilisations à des fins thérapeutiques ou pour la détection de cellules exprimant la protéine p53.

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