Dibenzoazulene derivatives for the treatment of thrombosis,...

C - Chemistry – Metallurgy – 07 – D

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C07D 213/74 (2006.01) A61K 31/4402 (2006.01) A61P 9/00 (2006.01) C07C 69/00 (2006.01) C07D 239/14 (2006.01)

Patent

CA 2367359

The invention relates to compounds of formula (I) wherein R1, R2, R3, m and n are defined as in claim 1 and to their physiologically acceptable salts and solvates. The inventive substances are used as integrin-inhibiting substances especially in the prophylaxis and treatment of cardiovascular disorders, of thrombosis, cardiac infarction, coronary heart diseases, arteriosclerosis, osteoporosis, in pathological conditions that are caused or propagated by the angiogenesis, and in tumor therapy.

Composés de formule (I) dans laquelle R?1¿, R?2¿, R?3¿, m et n possèdent la signification figurant à la revendication 1, ainsi que sels et solvates physiologiquement acceptables, qui peuvent être utilisés en tant qu'inhibiteurs d'intégrine, en particulier pour la prophylaxie et le traitement de troubles de la circulation, en cas de thrombose, d'infarctus du myocarde, de cardiopathies coronariennes, d'artériosclérose, d'ostéoporose, en cas de processus pathologiques qui sont entretenus ou propagés par l'angiogenèse et dans la thérapie antitumorale.

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