Phenacyl xanthine derivatives as dpp-iv inhibitor

Details Phenacyl xanthine derivatives as dpp-iv inhibitor Phenacyl xanthine derivatives as dpp-iv inhibitor

C - Chemistry, Metallurgy

07

D

C07D 473/04 (2006.01) A61K 31/52 (2006.01) A61P 3/10 (2006.01) C07D 473/06 (2006.01)

Patent

CA 2496325

The invention concerns substituted xanthines of general formula (I), wherein: R1 to R4 are such as defined in Claim 1, and tautomers, stereoisomers, mixtures, prodrugs and salts thereof. Said compounds have advantageous pharmacological properties, in particular an inhibiting effect on the activity of the dipeptidyl peptidase IV (DPP-IV) enzyme.

La présente invention concerne des xanthines substituées de formule générale (I), dans laquelle R?1¿ à R?4¿ sont tels que définis dans la revendication 1, ainsi que les tautomères, stéréoisomères, mélanges, promédicaments et sels de celles-ci. Ces composés possèdent des propriétés pharmacologiques avantageuses, notamment un effet inhibiteur sur l'activité de l'enzyme dipeptidyl peptidase IV (DPP-IV).

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