Process for preparing particles

Details Process for preparing particles Process for preparing particles

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 31/167 (2006.01) A61K 31/575 (2006.01) A61K 31/58 (2006.01) A61K 38/00 (2006.01) A61K 38/28 (2006.01) B01J 2/04 (2006.01) B05B 7/06 (2006.01)

Patent

CA 2433838

A process for preparing particles of a substance, such as a protein or polypeptide, comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator has a solubility in water which decreases with increasing temperature; and (b) contacting the first liquid with a second liquid comprising a fluid gas and an organic solvent using an anti-solvent fluid gas technique under conditions of temperature and pressure which result in the precipitation of particles comprising the substance, wherein the temperature of the first liquid is at or above the cloud point temperature of the first liquid when the first liquid contacts the second liquid. Also claimed are particles obtained according to the process and compositions containing the particles.

L'invention concerne un procédé de préparation de particules d'une substance, par exemple une protéine ou un polypeptide, qui consiste: (a) à préparer un premier liquide constitué d'eau, de la substance et d'un modulateur, ce dernier présentant une solubilité dans l'eau qui décroît lorsque la température augmente; et (b) à mettre en contact le premier liquide avec un second liquide constitué d'un fluide gazeux et d'un solvant organique par une technique de fluide gazeux anti-solvant dans des conditions de température et de pression donnant lieu à la précipitation de particules renfermant ladite substance. La température du premier liquide est égale ou supérieure à la température du point de trouble du premier liquide lorsque ce dernier entre en contact avec le second liquide. L'invention concerne également des particules obtenues selon le procédé ainsi que les compositions contenant ces particules.

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