C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/445 (2006.01) C07D 401/06 (2006.01)
Patent
CA 2586883
The present invention is directed to certain piperidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
L'invention porte sur des composés de piperidine qui sont utiles en tant qu'antagonistes du récepteur de neurokinine-1 (NK-1), et en tant qu'inhibiteurs de la tachykinine, notamment de la substance P. Cette invention se rapporte aussi à des formulations pharmaceutiques contenant ces composés en tant qu'ingrédients actifs, et à l'utilisation de ces composés ainsi qu'à leurs formulations dans le traitement de certains troubles, dont les vomissements, l'incontinence urinaire, la dépression et l'anxiété.
Devita Robert J.
Eid Ronsar
Mills Sander G.
Young Jonathan R.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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