Triazolo-pyridazine derivatives as ligands for gaba receptors

Details Triazolo-pyridazine derivatives as ligands for gaba receptors Triazolo-pyridazine derivatives as ligands for gaba receptors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/5025 (2006.01) A61P 25/00 (2006.01) C07D 237/00 (2006.01) C07D 249/00 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2362400

A class of substituted 1,2,4-triazolo[4,3-b]pyridazine derivatives, possessing an optionally substituted phenyl ring at the 3-position, and a C-substituted triazolyl-methoxy moiety at the 6-position, are selective ligands for GABAA receptors, in particular having high affinity for the .alpha.2 and/or .alpha.3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.

L'invention porte sur une classe de dérivés substitués de la 1,2,4-triazolo[4,3-b]pyridazine présentant un cycle phényle en position 3, et un fragment triazolyl-méthoxy à substitution C en position 6. Ces dérivés sont des liants sélectifs des récepteurs du GABA¿A? présentant en particulier une forte affinité pour des sous-unités .alpha.2 et/ou .alpha.3, et s'avérant de ce fait intéressants pour le traitement et/ou la prévention de troubles du SNC dont l'anxiété et les convulsions.

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